Several sources of documentation and help are available. If you don't see the answer to your question in the user's manual or in one of the examples, feel free to ask on the isis mailing list.
An introduction to ISIS for XSPEC users is also available.
Additional ISIS examples, tips and tutorials are available elsewhere on the web, including:
The primary software libraries used by ISIS provide their own documentation:
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This page is maintained by John C. Houck. Last updated: Feb 2, 2019